Bicalutamide USP Grade 98%min CAS NO.90357-06-5

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Bicalutimide

CAS RN: 90357-06-5

Chemical name: N-[4-Cyano-3-（trifluoromethyl）phenyl]-3-[（4-fluorophenyl）sulfonyl]-2-hydroxyl-2- methylpropanemide

Synonyms: Bicalutamide (Subject to patent free); 4-cyano-3-trifluoromethyl-N-(3-p-fluorophenylsulfonyl-2-hydroxy-2-methylpropionyl)aniline; N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methyl-propanamid; [(4- fluorophenyl) sulfonyl]-2-hydroxy- 2-methyl propanamide ; N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide; (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide

 

Molecular formula:C18H14F4N2O4S

molecular weight: 430.38

 

Characters: It’s a white or almost white crystal powder, odorless, tasteless, freely soluble in DMF; Soluble in butylene oxide; sparingly soluble in acetic ether and methanol; insoluble in water. 

 

Quality Standard: EP9.0/USP39

 

Specification:

Item	Standard
Appearance	White to off-white powder
Solubility	Freely soluble in tetrahydrofuran and acetone; soluble in acetonitrile; sparingly soluble in methanol; slightly soluble in alcohol.
Identification
A: infrared spectrum	Infrared absorption spectrohotometry confirm
B: hplc	The sample spectrum corresponds to standard
Specific optical rotation	+25.0° ～+27.5°
Residue on Ignition	NMT 0.1%
Heavy metals	NMT 10ppm
Water	NMT 0.2%
Organic impurities	NMT 0.1%
Bicalutamide aminobenzonitrile	NMT 0.1%
Bicalutamide relate compound A isomer A	NMT 0.1%
Bicalutamide relate compound A isomer B	NMT 0.1%
Desfluoro bicalutamide	NMT 0.2%
2-Fluoro bicalutamide	NMT 0.2%
Deoxybicalutamide	NMT 0.2%
Bicalutamide sulfide	NMT 0.1%
Any unspecified impurity	NMT 0.1%
Total impurities	NMT 0.5%
Residual Solvent	DMAC≤1090ppm
	Ethanol≤1000ppm
	Dichloromethane≤300ppm
	Ethyl acetate≤1000ppm
	MIBK≤1000ppm
	Petroleum ether≤1000ppm
	Benzene≤2ppm
Assay	98.0%-102.0%

Usage:

Prostate drug, It is developed by AstraZenca Internatioal,and it is the first antiandrogen non-corticosteroids drug for long-acting oral medication and firstly go on the market in 1995 in UK. An antiandrogen non-corticosteroids can be used treating prostate cancer in advanced stage as assistant drug, may also for treating prostate cancer in the early stage to play an important role.

 

Storage:

It should be kept in room temperature, and away from light; stored in sealed containers.

 

Packing: paper bucket, 25kg/package.